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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE4B All Species: 20.61
Human Site: T380 Identified Species: 50.37
UniProt: Q07343 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07343 NP_001032416.1 736 83343 T380 Q E R D L L K T F R I S S D T
Chimpanzee Pan troglodytes XP_001162426 729 82535 T373 Q E R D L L K T F R I S S D T
Rhesus Macaque Macaca mulatta XP_001091102 736 83341 T380 Q E R D L L K T F R I S S D T
Dog Lupus familis XP_536678 710 80315 L369 F V T Y M M T L E D H Y H S D
Cat Felis silvestris
Mouse Mus musculus Q01063 747 84544 T375 Q E R D L L K T F K I P V D T
Rat Rattus norvegicus P14646 736 83356 T380 Q E R D L L K T F K I S S D T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001086133 721 82347 D372 K T F K I P V D T L I T Y T M
Zebra Danio Brachydanio rerio XP_708955 713 80958 T372 T F V T Y M M T L E D H Y H Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W4S9 983 107322 S619 Q S R E L L T S L M I P P K T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22000 674 75370 P352 Q R L D D W G P D V F K I D E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 99.5 86.8 N.A. 71.8 96.5 N.A. N.A. N.A. 78.5 74.5 N.A. 44.5 N.A. 44.8 N.A.
Protein Similarity: 100 98.9 99.7 89.6 N.A. 81.7 98.2 N.A. N.A. N.A. 85.3 83 N.A. 56.1 N.A. 60.4 N.A.
P-Site Identity: 100 100 100 0 N.A. 80 93.3 N.A. N.A. N.A. 6.6 6.6 N.A. 40 N.A. 20 N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 86.6 100 N.A. N.A. N.A. 26.6 13.3 N.A. 53.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 60 10 0 0 10 10 10 10 0 0 60 10 % D
% Glu: 0 50 0 10 0 0 0 0 10 10 0 0 0 0 10 % E
% Phe: 10 10 10 0 0 0 0 0 50 0 10 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 10 10 10 10 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 70 0 10 0 0 % I
% Lys: 10 0 0 10 0 0 50 0 0 20 0 10 0 10 0 % K
% Leu: 0 0 10 0 60 60 0 10 20 10 0 0 0 0 0 % L
% Met: 0 0 0 0 10 20 10 0 0 10 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 10 0 0 0 20 10 0 0 % P
% Gln: 70 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Q
% Arg: 0 10 60 0 0 0 0 0 0 30 0 0 0 0 0 % R
% Ser: 0 10 0 0 0 0 0 10 0 0 0 40 40 10 0 % S
% Thr: 10 10 10 10 0 0 20 60 10 0 0 10 0 10 60 % T
% Val: 0 10 10 0 0 0 10 0 0 10 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 10 0 0 0 0 0 0 10 20 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _